MILESTONE International Conference
CK1 protein kinase family: From cell signaling to therapeutic targets in human disease
July 21–23, 2025
CEITEC MU, Brno, Czech Republic
CK1 (formerly named casein kinase 1) is a family of serine/threonine protein kinases crucial for regulating multiple cellular processes. Defects in CK1 regulation, localization, or mutations within the CK1 coding sequence are associated with important human diseases such as cancer, neurodegenerative diseases, and sleeping disorders. Consequently, members of the CK1 protein kinase family have emerged as promising targets for novel drug development, each paralog exhibiting distinct therapeutic effects. Furthermore, there is growing evidence linking CK1 to infectious diseases through the manipulation of its signaling pathways by pathogens.
The primary objective of this inaugural conference is to share the latest research findings on CK1. Beyond that, the conference aims to foster collaboration among diverse scientific communities engaged in CK1 research, thereby encouraging the exploration of new avenues in CK1-related studies. The conference sessions will encompass the following areas:
- CK1 in development and regeneration
- Exploring CK1 function in model organisms
- CK1 structure and mechanisms of regulation
- CK1 and circadian clocks
- CK1 in human diseases: cancer
- CK1 in human diseases: neurodegenerative diseases
- CK1 in human diseases: infectious diseases
- Spatial and temporal aspects of signaling
- Targeting CK1 for therapy
A round table will also be organized to discuss ways for different fields to collaborate on CK1 through dedicated funding.
