Program
Guidelines for presenters
All the submitted abstracts were accepted either for a talk (scheduled below) or for the poster.
We are excited to hear about your research!
Talks:
Talks selected from abstracts:
12 minutes lecture + 3 minutes discussion
supported by the slideshow
Invited speakers:
25 minutes lecture + 5 minutes discussion
supported by the slideshow
Posters:
Dimensions of posters:
A0 format (841 x 1 189 mm)
portrait orientation
DAY 1 (Monday 21/7)
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11:00–13:15
Registration
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13:15–13:30
Opening & Welcome
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13:30–15:00 Keynote speech block
13.30-14.30 David Virshup The CK1 family: Diverse targets, potent inhibitions 14.30-15.00 Uwe Knippschild CK1δ: Its role in tumorigenesis and -progression and its potential as therapeutic target -
15:00–15:30
Coffee Break
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15:30–17:00 Lectures: Targeting CK1
15.30-16.00 Stefan Knapp Selective Targeting of Casein Kinases 16.00-16.30 Yinon Ben-Neriah Cancer therapy based on co-targeting CKIα and transcriptional kinases 16.30-16.45 Kamil Paruch Discovery of new potent and exquisitely selective CK1 inhibitors 16.45-17.00 Tomasz Radaszkiewicz New potent and exquisitely selective CK1 inhibitors - applications in cancer -
17:00–17:30
Coffee Break
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17:30-19:00 Lectures: CK1 as a therapeutic target in infectious diseases
17.30-18.00 Najma Rachidi Leishmania Casein Kinase 1.2: A Dual-Function Kinase at the Host–Pathogen Interface 18.00-18.30 Pascal Marchand Targeting casein kinase 1 as a novel strategy for the design of anti-infective agents 18.30-18.45 Kojo Mensa-Wilmot Discovery of effectors for CK1 signaling in Trypanosoma brucei 18.45-19.00 Olivier Leclercq USING CELLULAR THERMAL SHIFT ASSAY TO ASSESS DRUG EFFICACY AGAINST LEISHMANIA CK1.2 -
19:00–23:00
Poster session - Barbecue/Beer/Wine
DAY 2 (Tuesday 22/7)
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09:00–10:30 Lectures: Biology of CK1
9.00-9.30 David Strutt Local recruitment of CKIε promotes cell-scale polarisation of the core planar polarity proteins in the developing Drosophila wing 9.30-10.00 Volker Dötsch The role of CK1 kinase family members in genetic quality control of oocytes 10.00-10.15 Jakub Harnoš CK1ε-Driven Planar Polarity as a Trigger for Neural Tube Formation 10.15-10.30 Sara Bologna CK1ε-DVL in Wnt signaling: more than a mere kinase-substrate relationship -
10:30–11:00
Coffee Break
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11:00–12:35 Lectures: Regulation of CK1 I
11.00-11.30 Kathy Gould Function and regulation of CK1 enzymes during the cell cycle 11.30-12.00 Kostas Tripsianes A proximity-based, stochastic autophosphorylation mechanism modulates casein kinase activity 12.00-12.20 Zbyněk Prokop Mechanistic Modeling of CK1 Catalysis Reveals Futile ATP Cycling That Outcompetes Autophosphorylation 12.20-12.35 Tianheng Zhu DEAD-box RNA helicase DDX3X regulates substrate specificity of CK1ε -
12:35–13:30
Lunch
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13:30–15:30 Lectures: Regulation of CK1 II
13.30-14.00 Vítězslav Bryja What makes a CK1 alpha a negative regulator of Wnt/beta-catenin pathway 14.00-14.30 Gopal Sapkota Regulation of CK1 family of protein kinases by FAM83 proteins in cellular signalling and human disease 14.30-14.45 Tyrell Cartwright HMMR/RHAMM is essential for the assembly of FAM83D-CK1a complex at the mitotic spindle to ensure proper spindle alignment 14.45-15.00 Jana Balounova FAM83H/SACK1H shapes thymic stromal architecture and postnatal lymphopoiesis via CK1 interaction 15.00-15.15 Michael Brunner Phosphorylation inactivates and stabilizes free CK1δ/ε during mitosis 15.15-15.30 Jan Mašek NOTCH1 phosphorylation by Casein Kinase 1α is essential for N1ICD transcriptional activity -
15:30–16:00
Coffee Break
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16:00–18:00
CasInvent Bussiness meeting
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18:00–23:00
Dinner and wine tasting in the wine cellar
DAY 3 (Wednesday 23/7)
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09:00–10:30 Lectures: CK1 in the regulation of circadian rythms
9.00-9.30 Rachel Harold/Carrie Partch Auto-regulation of Casein Kinase 1 through its intrinsically disordered C-terminus 9.30-9.45 Jiří Voller Cytokinin Derivatives as Modulators of Circadian Rhythms 9.45-10.00 Rebecca Spangler A conserved chronobiological complex times C. elegans development 10.00-10.15 David Doležel Evolution of Casein Kinase Genes in Animals 10.15-10.30 Maia Zabel The role of DBT/CK1ε in mediating temperature compensation in circadian clock neurons of Drosophila melanogaster -
10:30–11:00
Coffee Break
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11:00–12:00 Lectures: Novel CK1 tools
11.00-11.15 Jan Tykvart DIANA PANEL FOR KINASE INHIBITOR SELECTIVITY PROFILING: KEY TOOL FOR
EARLY DRUG DISCOVERY11.15-11.30 Stephanie Federico EXPLORING THE PYRAZINE SCAFFOLD TO DEVOLOP CASEIN KINASE 1δ INHIBITORS AS NEUROPROTECTIVE AGENTS 11.30-11.45 Jit Kong Cheong SFPQ promotes RAS-mutant cancer cell growth by modulating 5'-UTR mediated translational control of CK1α 11.45-12.00 Adrian Haag Development and Discovery of a Selective Degrader of Casein Kinases 1 δ/ε -
12:00–12:30 Closing lecture
12.00-12.30 Andrea Venerando/Lorenzo Pinna A Journey to the Centre of the hierarchical phosphorylation: the multifarious behavior of CK1 -
12:30–14:00
Lunch & Farewell